Reaction Details Report a problem with these data
Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM475676
Substrate
n/a
Meas. Tech.
Electrophysiology Assay
IC50
12.0±n/a nM
Citation
 Gunaga, P; Richter, J; Yadav, ND; Panda, M; Godesi, S Substituted bicyclic heterocyclic compounds US Patent  US10851108 Publication Date 12/1/2020 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM475676
Synonyms:
1-(6-(2-hydroxy-2-(4-methyl-1-oxo- 1,3-dihydroisobenzofuran-5-yl)ethyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin- 2-yl)-1H-pyrazole-4-carbonitrile (Enantiomer-I) | US10851108, Example 56-I
Type:
Small organic molecule
Emp. Form.:
C22H20N6O3
Mol. Mass.:
416.4326
SMILES:
Cc1c2COC(=O)c2ccc1C(O)CN1CCc2nc(ncc2C1)-n1cc(cn1)C#N
Structure:
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