Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM475677
Substrate
n/a
Meas. Tech.
Electrophysiology Assay
IC50
13.0±n/a nM
Citation
 Gunaga, PRichter, JYadav, NDPanda, MGodesi, S Substituted bicyclic heterocyclic compounds US Patent  US10851108 Publication Date 12/1/2020 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM475677
Synonyms:
5-(1-hydroxy-2-(2-(4-methyl-1H- imidazol-1-yl)-7,8-dihydropyrido[4,3-d] pyrimidin-6(5H)-yl)ethyl)-4-methyl isobenzofuran-1(3H)-one (Enantiomer-I) | US10851108, Example 58-I
Type:
Small organic molecule
Emp. Form.:
C22H23N5O3
Mol. Mass.:
405.4497
SMILES:
Cc1cn(cn1)-c1ncc2CN(CC(O)c3ccc4C(=O)OCc4c3C)CCc2n1
Structure:
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