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Target
Cyclin-dependent kinase 7
Ligand
BDBM395716
Substrate
n/a
Meas. Tech.
Kinase Activity Assay
IC50
550±n/a nM
Citation
 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, MA; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Inhibitors of cyclin-dependent kinase 7 (CDK7) US Patent  US10865206 Publication Date 12/15/2020 
Target
Name:
Cyclin-dependent kinase 7
Synonyms:
39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | CDK7_HUMAN | CDKN7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 (CDK7/cyclin H) | MO15 | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit
Type:
Enzyme Subunit
Mol. Mass.:
39047.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
346
Sequence:
MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
  
Inhibitor
Name:
BDBM395716
Synonyms:
4-amino-N-(1S,3R)-3-(5-chloro-4-(4H-indol-3-yl)pyrimidin-2-ylamino)cyclohexyl)-3-fluorobenzamide | US10308648, Compound 111 | US10865206, Compound 111
Type:
Small organic molecule
Emp. Form.:
C25H24ClFN6O
Mol. Mass.:
478.949
SMILES:
Nc1ccc(cc1F)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 |r|
Structure:
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