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Target
Mitogen-activated protein kinase 14
Ligand
BDBM476198
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
454±67 nM
Citation
 Laco, F; Low, JL; Oh, S; Chai, CL; Zhong, Q 2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis US Patent  US10865384 Publication Date 12/15/2020 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM476198
Synonyms:
US10865384, Compound IM-25 | US10865384, Example 3a
Type:
Small organic molecule
Emp. Form.:
C21H19FN2O2S
Mol. Mass.:
382.451
SMILES:
CS(=O)c1ccc(cc1)-c1nc(c([nH]1)C1=CCOCC1)-c1ccc(F)cc1 |t:16|
Structure:
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