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Target
Casein kinase I isoform delta
Ligand
BDBM476199
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
548±116 nM
Citation
 Laco, F; Low, JL; Oh, S; Chai, CL; Zhong, Q 2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis US Patent  US10865384 Publication Date 12/15/2020 
Target
Name:
Casein kinase I isoform delta
Synonyms:
CKI-delta | CKId | CSNK1D | Casein kinase 1 delta (CK1δ) | Casein kinase I delta | Casein kinase I isoform alpha/delta | Casein kinase I isoform delta (CK1D) | HCKID | KC1D_HUMAN | casein kinases 1 delta (CK1 delta)
Type:
Enzyme
Mol. Mass.:
47356.76
Organism:
Homo sapiens (Human)
Description:
P48730
Residue:
415
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
  
Inhibitor
Name:
BDBM476199
Synonyms:
US10865384, Compound IM-23 | US10865384, Example 3b
Type:
Small organic molecule
Emp. Form.:
C20H15F3N2O
Mol. Mass.:
356.3411
SMILES:
Fc1ccc(cc1)-c1nc([nH]c1C1=CCOCC1)-c1c(F)cccc1F |t:14|
Structure:
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