Reaction Details Report a problem with these data
Target
Capsid protein
Ligand
BDBM400038
Substrate
n/a
Meas. Tech.
HBV DNA Quantification Assay
EC50
64.5±n/a nM
Citation
Du, J; Kaplan, JA; Kirschberg, TA; Kobayashi, T; Lazerwith, SE; Lee, RA; Medley, JW; Mitchell, ML; Morganelli, PA; Pyun, H; Shevick, SL; Squires, NH; Watkins, WJ Substituted pyrrolizine compounds and uses thereof US Patent US10874640 Publication Date 12/29/2020
More Info.:
Target
Name:
Capsid protein
Synonyms:
C | CAPSD_HBVCJ | Core antigen | Core protein | HBcAg | p21.5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21105.01
Organism:
Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-) (HBV-C)
Description:
n/a
Residue:
183
Sequence:
MDIDPYKEFGASVELLSFLPSDFFPSIRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMNLATWVGSNLEDPASRELVVSYVNVNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSRESQC
Inhibitor
Name:
BDBM400038
Synonyms:
(R)-N-(3-chloro-4-fluorophenyl)-3,3,6-trimethyl-7-(2-oxo-2-((1,1,1-trifluoropropan-2-yl)amino)acetyl)-2,3-dihydro-1H-pyrrolizine-5-carboxamide | US10328053, Compound 17 | US10874640, Compound 17 | US20230270719, Compound 17
Type:
Small organic molecule
Emp. Form.:
C22H22ClF4N3O3
Mol. Mass.:
487.875
SMILES:
CC(NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2c1CCC2(C)C)C(F)(F)F