Reaction Details Report a problem with these data
Target
Histone deacetylase 3
Ligand
BDBM163623
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
157±28.55 nM
Citation
 Chou, CJ; McClure, J; Zhang, C; Inks, E Histone deacetylase inhibitors and uses thereof US Patent  US10870618 Publication Date 12/22/2020 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM163623
Synonyms:
SR-3206 | US10807944, Compound RLS2-126 | US10870618, Compound 1a | US11731934, Compound RLS2-126
Type:
Small organic molecule
Emp. Form.:
C12H18N2O2
Mol. Mass.:
222.2835
SMILES:
CCCCNNC(=O)c1ccc(OC)cc1
Structure:
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