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Target
Protein mono-ADP-ribosyltransferase TIPARP
Ligand
BDBM431117
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
<100±n/a nM
Citation
 Vasbinder, MM; Schenkel, LB; Swinger, KK; Kuntz, KW Pyridazinones as PARP7 inhibitors US Patent  US10870641 Publication Date 12/22/2020 
Target
Name:
Protein mono-ADP-ribosyltransferase TIPARP
Synonyms:
ADP-ribosyltransferase diphtheria toxin-like 14 | ARTD14 | PARP-7 | PARP7 | PARPT_HUMAN | Poly [ADP-ribose] polymerase 7 | TCDD-inducible poly [ADP-ribose] polymerase | TIPARP
Type:
Protein
Mol. Mass.:
76228.44
Organism:
Human
Description:
Q7Z3E1
Residue:
657
Sequence:
MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPILNTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQIPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQTDLLHPVSSDVPTSPDCLDKVIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFELVNQLQYHTHQENGIEICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDRMRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREYPESVIRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGGVPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNLFHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVDGICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGSHGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI
  
Inhibitor
Name:
BDBM431117
Synonyms:
6-[4-[2-([2-[(2S)-1-[6-oxo-5-(trifluoromethyl)-1,6-dihydropyridazin-4-yl]pyrrolidin-2-yl]ethyl]amino)acetyl]piperazin-1-yl]pyridine-3-carbonitrile | US10550105, Example 89 | US10870641, Example 89 | US11014913, Example 89
Type:
Small organic molecule
Emp. Form.:
C23H27F3N8O2
Mol. Mass.:
504.5081
SMILES:
FC(F)(F)c1c(cn[nH]c1=O)N1CCC[C@H]1CCNCC(=O)N1CCN(CC1)c1ccc(cn1)C#N |r|
Structure:
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