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Target
D(3) dopamine receptor
Ligand
BDBM476761
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
0.200±n/a nM
Citation
 Tobinaga, H; Masuda, K; Inagaki, M; Yonehara, M; Masuda, M Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect US Patent  US10870660 Publication Date 12/22/2020 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM476761
Synonyms:
US10870660, Compound III-037 | US11345716, Compound III-037
Type:
Small organic molecule
Emp. Form.:
C23H32F3N5O2S
Mol. Mass.:
499.593
SMILES:
Cn1cc(CC(=O)N[C@H]2CC[C@H](CCN3CCc4nc(OCC(F)(F)F)sc4CC3)CC2)cn1 |r,wU:11.11,wD:8.7,(13.14,2.84,;11.6,2.84,;10.57,3.99,;9.17,3.36,;7.83,4.13,;6.5,3.36,;6.5,1.82,;5.17,4.13,;3.83,3.36,;2.5,4.13,;1.17,3.36,;1.17,1.82,;-.17,1.05,;-1.5,1.82,;-2.84,1.05,;-4.11,1.92,;-5.58,1.46,;-6.14,.03,;-7.65,-.29,;-7.81,-1.82,;-9.14,-2.59,;-10.48,-1.82,;-11.81,-2.59,;-13.14,-1.82,;-11.81,-4.13,;-13.14,-3.36,;-6.4,-2.45,;-5.37,-1.3,;-3.85,-1.53,;-2.72,-.48,;2.5,1.05,;3.83,1.82,;9.33,1.83,;10.83,1.51,)|
Structure:
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