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Target
D(3) dopamine receptor
Ligand
BDBM476869
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
0.095±n/a nM
Citation
 Tobinaga, H; Masuda, K; Inagaki, M; Yonehara, M; Masuda, M Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect US Patent  US10870660 Publication Date 12/22/2020 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM476869
Synonyms:
US10870660, Compound II-077 | US11345716, Compound II-077
Type:
Small organic molecule
Emp. Form.:
C25H33F3N4O4
Mol. Mass.:
510.5491
SMILES:
COc1cc(CC(=O)N[C@H]2CC[C@H](CCN3CCc4ccc(OCC(F)(F)F)nc4CC3)CC2)on1 |r,wU:12.12,wD:9.8,(13.88,.76,;13.11,2.1,;11.57,2.1,;10.54,3.24,;9.13,2.61,;7.8,3.38,;6.46,2.61,;6.46,1.07,;5.13,3.38,;3.8,2.61,;2.46,3.38,;1.13,2.61,;1.13,1.07,;-.2,.3,;-1.54,1.07,;-2.87,.3,;-2.76,-1.23,;-3.89,-2.28,;-5.41,-2.05,;-6.18,-3.38,;-7.72,-3.38,;-8.49,-2.05,;-10.03,-2.05,;-10.8,-.72,;-12.34,-.72,;-13.11,.62,;-13.11,-2.05,;-13.88,-.72,;-7.72,-.72,;-6.18,-.72,;-5.62,.72,;-4.14,1.17,;2.46,.3,;3.8,1.07,;9.29,1.08,;10.8,.76,)|
Structure:
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