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Target
Prolyl hydroxylase EGLN3
Ligand
BDBM477198
Substrate
n/a
Meas. Tech.
EGLN-1 Activity Assay
IC50
210±3.5 nM
Citation
 You, Q; Zhang, X; Lei, Y; Hu, T; Wu, X; Sun, H; Guo, X; Xu, X Alkynyl pyridine prolyl hydroxylase inhibitor, and preparation method and medical use thereof US Patent  US10889546 Publication Date 1/12/2021 
Target
Name:
Prolyl hydroxylase EGLN3
Synonyms:
EGLN3 | EGLN3_HUMAN | Egl nine homolog 3 (EGLIN3) | Egl nine homolog 3 (EGLN3)
Type:
Protein
Mol. Mass.:
27265.54
Organism:
Homo sapiens (Human)
Description:
Q9H6Z9
Residue:
239
Sequence:
MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCTGALRDGQLAGPRAGVSKRHLRGDQITWIGGNEEGCEAISFLLSLIDRLVLYCGSRLGKYYVKERSKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALTED
  
Inhibitor
Name:
BDBM477198
Synonyms:
US10889546, Example 8
Type:
Small organic molecule
Emp. Form.:
C17H13ClN2O5
Mol. Mass.:
360.749
SMILES:
OCc1ccc(cc1)C#Cc1cc(O)c(nc1Cl)C(=O)NCC(O)=O
Structure:
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