Reaction Details Report a problem with these data
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM477585
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
735±n/a nM
Citation
 Lain, S; Drummond, C; Leeuwen, IV; Haraldsson, M; Johansson, L; Sandberg, L; Yngve, U Tetrahydroindazoles and medical uses thereof US Patent  US10889564 Publication Date 1/12/2021 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM477585
Synonyms:
N-[(4R*)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl]-5-methylpyrazine-2-carboxamide (* putative isomer) | US10889564, Example 15
Type:
Small organic molecule
Emp. Form.:
C19H18FN5O
Mol. Mass.:
351.3775
SMILES:
Cc1cnc(cn1)C(=O)N[C@@H]1CCCc2c1cnn2-c1ccccc1F |r|
Structure:
Search PDB for entries with ligand similarity: