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Target
Short transient receptor potential channel 6
Ligand
BDBM466602
Substrate
n/a
Meas. Tech.
High Throughput Screening Assay
IC50
31.0±n/a nM
Citation
 Bouyssou, T; Gottschling, D; Heine, N; Smith Keenan, LL; Lowe, MD; Razavi, H; Sarko, CR; Surprenant, S; Takahashi, H; Turner, MR; Wu, X Inhibitors of TRPC6 US Patent  US10889568 Publication Date 1/12/2021 
Target
Name:
Short transient receptor potential channel 6
Synonyms:
TRP-6 | TRP6 | TRPC6 | TRPC6_HUMAN | Transient receptor protein 6
Type:
PROTEIN
Mol. Mass.:
106326.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107640
Residue:
931
Sequence:
MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGSDNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRELGEKLSMEPNQEETNR
  
Inhibitor
Name:
BDBM466602
Synonyms:
US10800757, Compound 18 | US10889568, Compound 18 | [(R)-4-(6-Amino-4-methyl-pyridin-3- yl)-2-hydroxymethyl-piperazin-1-yl]- (4-methoxy-5-phenoxy-pyridin-2-yl)- methanone
Type:
Small organic molecule
Emp. Form.:
C24H27N5O4
Mol. Mass.:
449.5023
SMILES:
COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(C[C@@H]1CO)c1cnc(N)cc1C |r|
Structure:
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