Reaction Details Report a problem with these data
Target
Short transient receptor potential channel 6
Ligand
BDBM466628
Substrate
n/a
Meas. Tech.
High Throughput Screening Assay
IC50
140±n/a nM
Citation
Bouyssou, T; Gottschling, D; Heine, N; Smith Keenan, LL; Lowe, MD; Razavi, H; Sarko, CR; Surprenant, S; Takahashi, H; Turner, MR; Wu, X Inhibitors of TRPC6 US Patent US10889568 Publication Date 1/12/2021
More Info.:
Target
Name:
Short transient receptor potential channel 6
Synonyms:
TRP-6 | TRP6 | TRPC6 | TRPC6_HUMAN | Transient receptor protein 6
Type:
PROTEIN
Mol. Mass.:
106326.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107640
Residue:
931
Sequence:
MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGSDNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRELGEKLSMEPNQEETNR
Inhibitor
Name:
BDBM466628
Synonyms:
US10800757, Compound 44 | US10889568, Compound 44 | [4-(6-Amino-pyridazin-3-yl)-piperidin- 1-yl]-[4-methoxy-5-(4-methoxy- phenoxy)-pyridin-2-yl]-methanone
Type:
Small organic molecule
Emp. Form.:
C23H25N5O4
Mol. Mass.:
435.4757
SMILES:
COc1ccc(Oc2cnc(cc2OC)C(=O)N2CCC(CC2)c2ccc(N)nn2)cc1