Reaction Details Report a problem with these data
Target
Vasopressin V1a receptor
Ligand
BDBM477630
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
IC50
1200±n/a nM
Citation
 Li, X; He, W; Wang, B; Zhang, Z; He, F; Tao, W Condensed ring group azacyclobutyl triazole derivative, preparation method therefor and use thereof in medicine US Patent  US10889569 Publication Date 1/12/2021 
Target
Name:
Vasopressin V1a receptor
Synonyms:
AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
46820.18
Organism:
Homo sapiens (Human)
Description:
P37288
Residue:
418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
  
Inhibitor
Name:
BDBM477630
Synonyms:
5-(3-(3-(6-Fluorobenzo[b]thiophen-3-yl)azetidin-1-yl)-5-(methoxymethyl)-4H-1,2,4-triazol-4-yl)-2-methoxypyridine 9 | US10889569, Example 9
Type:
Small organic molecule
Emp. Form.:
C21H20FN5O2S
Mol. Mass.:
425.479
SMILES:
COCc1nnc(N2CC(C2)c2csc3cc(F)ccc23)n1-c1ccc(OC)nc1
Structure:
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