Reaction Details Report a problem with these data
Target
Vasopressin V1a receptor
Ligand
BDBM477653
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
IC50
1700±n/a nM
Citation
 Li, X; He, W; Wang, B; Zhang, Z; He, F; Tao, W Condensed ring group azacyclobutyl triazole derivative, preparation method therefor and use thereof in medicine US Patent  US10889569 Publication Date 1/12/2021 
Target
Name:
Vasopressin V1a receptor
Synonyms:
AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
46820.18
Organism:
Homo sapiens (Human)
Description:
P37288
Residue:
418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
  
Inhibitor
Name:
BDBM477653
Synonyms:
4-(1-(5-((Difluoromethoxy)methyl)-4-(6-methoxypyridin-3-yl)-4H-1,2,4-triazol-3-yl) azetidin-3-yl)-7-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine 37 | US10889569, Example 37
Type:
Small organic molecule
Emp. Form.:
C21H21F3N6O3
Mol. Mass.:
462.425
SMILES:
COc1ccc(cn1)-n1c(COC(F)F)nnc1N1CC(C1)N1CCOc2cc(F)ccc12
Structure:
Search PDB for entries with ligand similarity: