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Target
Vasopressin V2 receptor
Ligand
BDBM477659
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
IC50
9100±n/a nM
Citation
 Li, X; He, W; Wang, B; Zhang, Z; He, F; Tao, W Condensed ring group azacyclobutyl triazole derivative, preparation method therefor and use thereof in medicine US Patent  US10889569 Publication Date 1/12/2021 
Target
Name:
Vasopressin V2 receptor
Synonyms:
ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
40295.28
Organism:
Homo sapiens (Human)
Description:
P30518
Residue:
371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
  
Inhibitor
Name:
BDBM477659
Synonyms:
1-(1-(4-(Benzo[d][1,3]dioxolan-5-yl)-5-(ethoxymethyl)-4H-1,2,4-triazol-3-yl)azetidin-3-yl)-6-fluoro-1,2,3,4-tetrahydroquinoline 27 | US10889569, Example 27
Type:
Small organic molecule
Emp. Form.:
C24H26FN5O3
Mol. Mass.:
451.4933
SMILES:
CCOCc1nnc(N2CC(C2)N2CCCc3cc(F)ccc23)n1-c1ccc2OCOc2c1
Structure:
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