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Target
Ubiquitin carboxyl-terminal hydrolase 28
Ligand
BDBM478039
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
1100±n/a nM
Citation
 Guerin, DJ; Bair, KW; Caravella, JA; Ioannidis, Jr., S; Lancia, Jr., DR; Li, H; Mischke, S; Ng, PY; Richard, D; Schiller, SE; Shelekhin, T; Wang, Z Thienopyrazine carboxamides as ubiquitin-specific protease inhibitors US Patent  US10889592 Publication Date 1/12/2021 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 28
Synonyms:
3.4.19.12 | Deubiquitinating enzyme 28 | KIAA1515 | UBP28_HUMAN | USP28 | Ubiquitin carboxyl-terminal hydrolase 28 | Ubiquitin thioesterase 28 | Ubiquitin-specific-processing protease 28
Type:
PROTEIN
Mol. Mass.:
122456.92
Organism:
Homo sapiens
Description:
ChEMBL_105199
Residue:
1077
Sequence:
MTAELQQDDAAGAADGHGSSCQMLLNQLREITGIQDPSFLHEALKASNGDITQAVSLLTDERVKEPSQDTVATEPSEVEGSAANKEVLAKVIDLTHDNKDDLQAAIALSLLESPKIQADGRDLNRMHEATSAETKRSKRKRCEVWGENPNPNDWRRVDGWPVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNVLENCRSHTEKRNIMFMQELQYLFALMMGSNRKFVDPSAALDLLKGAFRSSEEQQQDVSEFTHKLLDWLEDAFQLAVNVNSPRNKSENPMVQLFYGTFLTEGVREGKPFCNNETFGQYPLQVNGYRNLDECLEGAMVEGDVELLPSDHSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQIIYMDRYMYRSKELIRNKRECIRKLKEEIKILQQKLERYVKYGSGPARFPLPDMLKYVIEFASTKPASESCPPESDTHMTLPLSSVHCSVSDQTSKESTSTESSSQDVESTFSSPEDSLPKSKPLTSSRSSMEMPSQPAPRTVTDEEINFVKTCLQRWRSEIEQDIQDLKTCIASTTQTIEQMYCDPLLRQVPYRLHAVLVHEGQANAGHYWAYIYNQPRQSWLKYNDISVTESSWEEVERDSYGGLRNVSAYCLMYINDKLPYFNAEAAPTESDQMSEVEALSVELKHYIQEDNWRFEQEVEEWEEEQSCKIPQMESSTNSSSQDYSTSQEPSVASSHGVRCLSSEHAVIVKEQTAQAIANTARAYEKSGVEAALSEVMLSPAMQGVILAIAKARQTFDRDGSEAGLIKAFHEEYSRLYQLAKETPTSHSDPRLQHVLVYFFQNEAPKRVVERTLLEQFADKNLSYDERSISIMKVAQAKLKEIGPDDMNMEEYKKWHEDYSLFRKVSVYLLTGLELYQKGKYQEALSYLVYAYQSNAALLMKGPRRGVKESVIALYRRKCLLELNAKAASLFETNDDHSVTEGINVMNELIIPCIHLIINNDISKDDLDAIEVMRNHWCSYLGQDIAENLQLCLGEFLPRLLDPSAEIIVLKEPPTIRPNSPYDLCSRFAAVMESIQGVSTVTVK
  
Inhibitor
Name:
BDBM478039
Synonyms:
US10889592, Compound I-16 | US11325917, Compound I-16
Type:
Small organic molecule
Emp. Form.:
C23H27FN6OS
Mol. Mass.:
454.563
SMILES:
C[C@H](CNC(=O)c1sc2nc(C)cnc2c1N)c1ccc(cc1F)N1CC2CCC(C1)N2 |r,TLB:20:24:31:27.28|
Structure:
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