Target
Solute carrier family 22 member 12
Ligand
BDBM478085
Substrate
n/a
Meas. Tech.
URAT1 In Vitro Inhibition Activity-Method A
IC50
66.0±n/a nM
Citation
 Li, TZhao, XYu, CTan, HWang, XTan, RLiu, BZhang, WZhang, HLiu, QZhou, ZLi, ZRong, YSun, JWang, W Indolizine derivatives, composition and methods of use US Patent  US10894038 Publication Date 1/19/2021 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM478085
Synonyms:
2-((3-(8-cyanoindolizin-5-yl)pyridin-4-yl)thio)-2-methylpropanoic acid | US10894038, Example 2
Type:
Small organic molecule
Emp. Form.:
C18H15N3O2S
Mol. Mass.:
337.396
SMILES:
CC(C)(Sc1ccncc1-c1ccc(C#N)c2cccn12)C(O)=O
Structure:
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