Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM478097
Substrate
n/a
Meas. Tech.
URAT1 In Vitro Inhibition Activity-Method B
IC50
29.0±n/a nM
Citation
 Li, T; Zhao, X; Yu, C; Tan, H; Wang, X; Tan, R; Liu, B; Zhang, W; Zhang, H; Liu, Q; Zhou, Z; Li, Z; Rong, Y; Sun, J; Wang, W Indolizine derivatives, composition and methods of use US Patent  US10894038 Publication Date 1/19/2021 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM478097
Synonyms:
1-((3-(2-bromo-8-cyanoindolizin-5-yl)pyridin- 4-yl)thio)cyclobutane-1-carboxylic acid | US10894038, Example 15
Type:
Small organic molecule
Emp. Form.:
C19H14BrN3O2S
Mol. Mass.:
428.302
SMILES:
OC(=O)C1(CCC1)Sc1ccncc1-c1ccc(C#N)c2cc(Br)cn12
Structure:
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