Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM479525
Substrate
n/a
Meas. Tech.
Binding Affinity Assay
IC50
2.40±n/a nM
Citation
 Qi, C; Tsui, H; Zeng, Q; Yang, Z; Zhang, X Pyrazine compounds and uses thereof US Patent  US10898481 Publication Date 1/26/2021 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM479525
Synonyms:
3-amino-N-((3-fluoropyridin-2-yl) methyl)-6-(3-methylimidazo[1,2-a] pyridin-6-yl)-5-(oxazol-2-yl)pyrazine-2- carboxamide | US10898481, Compound 101 | US11571420, Compound 101
Type:
Small organic molecule
Emp. Form.:
C22H17FN8O2
Mol. Mass.:
444.4212
SMILES:
Cc1cnc2ccc(cn12)-c1nc(C(=O)NCc2ncccc2F)c(N)nc1-c1ncco1
Structure:
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