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Target
Adenosine receptor A1
Ligand
BDBM479533
Substrate
n/a
Meas. Tech.
Binding Affinity Assay
IC50
161±n/a nM
Citation
 Qi, C; Tsui, H; Zeng, Q; Yang, Z; Zhang, X Pyrazine compounds and uses thereof US Patent  US10898481 Publication Date 1/26/2021 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM479533
Synonyms:
3-amino-6-(3-methylimidazo[1,2-a] pyridin-6-yl)-5-(oxazol-2-yl)-N-(oxetan-2- ylmethyl)pyrazine-2-carboxamide (isomer 1) | US10898481, Compound 134 | US10898481, Compound 135 | US11571420, Compound 135
Type:
Small organic molecule
Emp. Form.:
C20H19N7O3
Mol. Mass.:
405.41
SMILES:
Cc1cnc2ccc(cn12)-c1nc(C(=O)NCC2CCO2)c(N)nc1-c1ncco1
Structure:
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