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Target
Adenosine receptor A1
Ligand
BDBM479537
Substrate
n/a
Meas. Tech.
Binding Affinity Assay
IC50
17.0±n/a nM
Citation
 Qi, C; Tsui, H; Zeng, Q; Yang, Z; Zhang, X Pyrazine compounds and uses thereof US Patent  US10898481 Publication Date 1/26/2021 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM479537
Synonyms:
(R)-3-amino-5-(4-fluorophenyl)-6-(3- methylimidazo[1,2-a]pyridin-6-yl)-N- ((1-methylpyrrolidin-2-yl)methyl) pyrazine-2-carboxamide | US10898481, Compound 138 | US11571420, Compound 138
Type:
Small organic molecule
Emp. Form.:
C25H26FN7O
Mol. Mass.:
459.5186
SMILES:
CN1CCC[C@@H]1CNC(=O)c1nc(-c2ccc3ncc(C)n3c2)c(nc1N)-c1ccc(F)cc1 |r|
Structure:
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