Target
TGF-beta receptor type-1
Ligand
BDBM480002
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
241±n/a nM
Citation
 Yang, FZhang, LShen, GHe, FTao, W 3,4-bipyridyl pyrazole derivative, and preparation method therefor and medical application thereof US Patent  US10899741 Publication Date 1/26/2021 
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Homo sapiens (Human)
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM480002
Synonyms:
4-(1-Cyclopentyl-3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-2-(4-(methylsulfonyl)phenyl)pyridine | US10899741, Example 3
Type:
Small organic molecule
Emp. Form.:
C26H26N4O2S
Mol. Mass.:
458.575
SMILES:
Cc1cccc(n1)-c1nn(cc1-c1ccnc(c1)-c1ccc(cc1)S(C)(=O)=O)C1CCCC1
Structure:
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