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Target
Mitogen-activated protein kinase 14
Ligand
BDBM479981
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
2200±n/a nM
Citation
 Yang, F; Zhang, L; Shen, G; He, F; Tao, W 3,4-bipyridyl pyrazole derivative, and preparation method therefor and medical application thereof US Patent  US10899741 Publication Date 1/26/2021 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM479981
Synonyms:
4-(1-Cyclobutyl-3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-2-(4-(methylsulfonyl)phenyl)pyridine | US10899741, Example 1
Type:
Small organic molecule
Emp. Form.:
C25H24N4O2S
Mol. Mass.:
444.549
SMILES:
Cc1cccc(n1)-c1nn(cc1-c1ccnc(c1)-c1ccc(cc1)S(C)(=O)=O)C1CCC1
Structure:
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