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Target
Apelin receptor
Ligand
BDBM481012
Substrate
n/a
Meas. Tech.
[35S]GTPγS Binding Assay
EC50
7.30±n/a nM
Citation
 Chen, N; Chen, Y; Debenedetto, MV; Dransfield, PJ; Harvey, JS; Heath, JA; Houze, J; Khakoo, AY; Lai, S; Ma, Z; Nishimura, N; Pattaropong, V; Swaminath, G; Yeh, W; Kreiman, C Triazole phenyl compounds as agonists of the APJ receptor US Patent  US10906890 Publication Date 2/2/2021 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM481012
Synonyms:
US10906890, Example 21.0
Type:
Small organic molecule
Emp. Form.:
C25H26FN7O4S
Mol. Mass.:
539.582
SMILES:
COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H]2CCCN(C2)c2ncc(F)cn2)nnc1-c1ccccc1 |r,wU:16.16,(-8.03,6.13,;-6.69,5.36,;-5.36,6.13,;-5.36,7.67,;-4.02,8.44,;-2.69,7.67,;-2.69,6.13,;-1.36,5.36,;-.02,6.13,;-4.02,5.36,;-4.02,3.82,;-2.78,2.92,;-1.29,3.32,;-.2,2.23,;.89,1.14,;-1.29,1.14,;.89,3.32,;.49,4.81,;1.58,5.89,;3.06,5.5,;3.46,4.01,;2.37,2.92,;4.95,3.61,;5.35,2.12,;6.84,1.72,;7.93,2.81,;9.41,2.41,;7.53,4.3,;6.04,4.7,;-3.25,1.45,;-4.79,1.45,;-5.27,2.92,;-6.76,3.32,;-7.16,4.81,;-8.64,5.2,;-9.73,4.11,;-9.33,2.63,;-7.85,2.23,)|
Structure:
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