Target
Apelin receptor
Ligand
BDBM481016
Substrate
n/a
Meas. Tech.
[35S]GTPγS Binding Assay
EC50
1.30±n/a nM
Citation
 Chen, NChen, YDebenedetto, MVDransfield, PJHarvey, JSHeath, JAHouze, JKhakoo, AYLai, SMa, ZNishimura, NPattaropong, VSwaminath, GYeh, WKreiman, C Triazole phenyl compounds as agonists of the APJ receptor US Patent  US10906890 Publication Date 2/2/2021 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM481016
Synonyms:
US10906890, Example 25.0
Type:
Small organic molecule
Emp. Form.:
C25H28N6O4S
Mol. Mass.:
508.593
SMILES:
COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2cnc(C)cn2)nnc1-c1ccccc1 |r,wU:16.17,18.19,(-6.44,1.3,;-5.1,.53,;-3.77,1.3,;-3.77,2.84,;-2.44,3.61,;-1.1,2.84,;-1.1,1.3,;.23,.53,;1.56,1.3,;-2.44,.53,;-2.44,-1.01,;-1.19,-1.91,;.27,-1.44,;1.42,-2.47,;2.56,-3.5,;.39,-3.61,;2.45,-1.32,;1.97,.14,;3.95,-1.64,;4.43,-3.11,;4.99,-.5,;4.51,.97,;5.54,2.11,;7.05,1.79,;8.08,2.93,;7.52,.33,;6.49,-.82,;-1.67,-3.38,;-3.21,-3.38,;-3.68,-1.91,;-5.15,-1.44,;-5.47,.07,;-6.93,.55,;-8.08,-.49,;-7.76,-1.99,;-6.29,-2.47,)|
Structure:
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