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Target
Apelin receptor
Ligand
BDBM481020
Substrate
n/a
Meas. Tech.
[35S]GTPγS Binding Assay
EC50
390±n/a nM
Citation
 Chen, N; Chen, Y; Debenedetto, MV; Dransfield, PJ; Harvey, JS; Heath, JA; Houze, J; Khakoo, AY; Lai, S; Ma, Z; Nishimura, N; Pattaropong, V; Swaminath, G; Yeh, W; Kreiman, C Triazole phenyl compounds as agonists of the APJ receptor US Patent  US10906890 Publication Date 2/2/2021 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM481020
Synonyms:
US10906890, Example 29.0
Type:
Small organic molecule
Emp. Form.:
C24H27N9O4S
Mol. Mass.:
537.594
SMILES:
COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@H]2CCCN(C2)c2ncc(C)cn2)nnc1-c1ccccc1 |r,wU:16.16,(-8.06,6.04,;-6.72,5.27,;-5.39,6.04,;-5.39,7.58,;-4.06,8.35,;-2.72,7.58,;-2.72,6.04,;-1.39,5.27,;-.06,6.04,;-4.06,5.27,;-4.06,3.73,;-2.81,2.82,;-1.32,3.22,;-.23,2.13,;.85,1.04,;-1.32,1.04,;.85,3.22,;.46,4.71,;1.54,5.8,;3.03,5.4,;3.43,3.91,;2.34,2.82,;4.92,3.51,;5.32,2.03,;6.8,1.63,;7.89,2.72,;9.38,2.32,;7.49,4.2,;6.01,4.6,;-3.29,1.36,;-4.83,1.36,;-5.3,2.82,;-6.79,3.22,;-7.19,4.71,;-8.68,5.11,;-9.77,4.02,;-9.37,2.53,;-7.88,2.13,)|
Structure:
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