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Target
Apelin receptor
Ligand
BDBM481046
Substrate
n/a
Meas. Tech.
[35S]GTPγS Binding Assay
EC50
86.0±n/a nM
Citation
 Chen, N; Chen, Y; Debenedetto, MV; Dransfield, PJ; Harvey, JS; Heath, JA; Houze, J; Khakoo, AY; Lai, S; Ma, Z; Nishimura, N; Pattaropong, V; Swaminath, G; Yeh, W; Kreiman, C Triazole phenyl compounds as agonists of the APJ receptor US Patent  US10906890 Publication Date 2/2/2021 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM481046
Synonyms:
US10906890, Example 58.0 | US10906890, Example 59.0
Type:
Small organic molecule
Emp. Form.:
C28H32FN7O5S
Mol. Mass.:
597.661
SMILES:
COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H]2C[C@H](CN(C2)c2ncc(F)cn2)OC(C)C)nnc1-c1ccccc1 |r,wU:16.16,18.31,(-7.32,2.83,;-5.99,2.06,;-4.65,2.83,;-4.65,4.37,;-3.32,5.14,;-1.99,4.37,;-1.99,2.83,;-.65,2.06,;.68,2.83,;-3.32,2.06,;-3.32,.52,;-2.07,-.39,;-.61,.09,;.53,-.94,;-.24,-2.27,;1.3,-2.27,;2,-.46,;2.32,1.04,;3.78,1.52,;4.93,.49,;4.61,-1.02,;3.14,-1.49,;5.75,-2.05,;5.43,-3.56,;6.58,-4.59,;8.04,-4.11,;9.19,-5.14,;8.36,-2.6,;7.22,-1.57,;4.1,3.02,;5.57,3.5,;5.89,5.01,;6.71,2.47,;-2.55,-1.85,;-4.09,-1.85,;-4.57,-.39,;-6.11,-.39,;-6.88,.95,;-8.42,.95,;-9.19,-.39,;-8.42,-1.72,;-6.88,-1.72,)|
Structure:
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