Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM481048
Substrate
n/a
Meas. Tech.
[35S]GTPγS Binding Assay
EC50
350±n/a nM
Citation
 Chen, N; Chen, Y; Debenedetto, MV; Dransfield, PJ; Harvey, JS; Heath, JA; Houze, J; Khakoo, AY; Lai, S; Ma, Z; Nishimura, N; Pattaropong, V; Swaminath, G; Yeh, W; Kreiman, C Triazole phenyl compounds as agonists of the APJ receptor US Patent  US10906890 Publication Date 2/2/2021 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM481048
Synonyms:
US10906890, Example 60.0
Type:
Small organic molecule
Emp. Form.:
C21H18BrN5O4S
Mol. Mass.:
516.368
SMILES:
COc1cccc(OC)c1-n1c(NS(=O)(=O)c2cncc(Br)c2)nnc1-c1ccccc1 |(-5.6,1.4,;-4.27,.63,;-2.94,1.4,;-2.94,2.94,;-1.6,3.71,;-.27,2.94,;-.27,1.4,;1.06,.63,;2.4,1.4,;-1.6,.63,;-1.6,-.91,;-.36,-1.82,;1.11,-1.34,;2.25,-2.37,;1.48,-3.71,;3.02,-3.71,;3.72,-1.9,;4.04,-.39,;5.5,.09,;6.65,-.95,;6.33,-2.45,;7.47,-3.48,;4.86,-2.93,;-.83,-3.28,;-2.37,-3.28,;-2.85,-1.82,;-4.39,-1.82,;-5.16,-.48,;-6.7,-.48,;-7.47,-1.82,;-6.7,-3.15,;-5.16,-3.15,)|
Structure:
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