Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM481058
Substrate
n/a
Meas. Tech.
[35S]GTPγS Binding Assay
EC50
3.80±n/a nM
Citation
Chen, N; Chen, Y; Debenedetto, MV; Dransfield, PJ; Harvey, JS; Heath, JA; Houze, J; Khakoo, AY; Lai, S; Ma, Z; Nishimura, N; Pattaropong, V; Swaminath, G; Yeh, W; Kreiman, C Triazole phenyl compounds as agonists of the APJ receptor US Patent US10906890 Publication Date 2/2/2021
More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM481058
Synonyms:
US10906890, Example 70.0
Type:
Small organic molecule
Emp. Form.:
C25H26Cl2N6O5S
Mol. Mass.:
593.482
SMILES:
CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(Cl)c(Cl)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(5.51,-3.92,;4.18,-3.15,;4.18,-1.61,;2.84,-.84,;2.84,.7,;1.51,-1.61,;.17,-2.38,;2.84,-2.38,;.17,-.84,;-1.16,-1.61,;-1.64,-3.07,;-3.18,-3.07,;-3.65,-1.61,;-5.12,-1.13,;-5.44,.37,;-6.9,.85,;-8.05,-.18,;-9.51,.3,;-7.73,-1.69,;-8.87,-2.72,;-6.26,-2.16,;-2.41,-.7,;-2.41,.84,;-3.74,1.61,;-5.07,.84,;-6.41,1.61,;-3.74,3.15,;-2.41,3.92,;-1.07,3.15,;-1.07,1.61,;.26,.84,;1.6,1.61,;5.51,-.84,;6.84,-1.61,;8.18,-.84,;8.18,.7,;9.51,1.47,;6.84,1.47,;5.51,.7,)|