Target
Transient receptor potential cation channel subfamily A member 1
Ligand
BDBM481850
Substrate
n/a
Meas. Tech.
FLIPR Assay
IC50
16.8±n/a nM
Citation
 Chen, HShore, DVillemure, EVolgraf, MHu, BLu, ACridland, AWard, SBeaumier, FDery, MLarouche-Gauthier, R Oxadiazolones as transient receptor potential channel inhibitors US Patent  US10913742 Publication Date 2/9/2021 
Target
Name:
Transient receptor potential cation channel subfamily A member 1
Synonyms:
ANKTM1 | Ankyrin-like with transmembrane domains protein 1 | TRPA1 | TRPA1_HUMAN | Transformation-sensitive protein p120 | Transient receptor potential cation channel subfamily A member 1 (TRPA1)
Type:
Protein
Mol. Mass.:
127514.20
Organism:
Homo sapiens (Human)
Description:
O75762
Residue:
1119
Sequence:
MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNFKYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIFCFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETEDDDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP
  
Inhibitor
Name:
BDBM481850
Synonyms:
US10913742, Example 94 | trans-3-[3-(4-chlorophenyl)-3- fluoro-cyclobutyl]-5-[(4- oxopyrido[2,3-d]pyrimidin-3- yl)methyl]-1,3,4-oxadiazol- 2-one
Type:
Small organic molecule
Emp. Form.:
C20H15ClFN5O3
Mol. Mass.:
427.816
SMILES:
F[C@@]1(C[C@@H](C1)n1nc(Cn2cnc3ncccc3c2=O)oc1=O)c1ccc(Cl)cc1 |r,wD:3.5,1.0,(4.79,.91,;4.01,-.42,;2.78,-1.35,;1.86,-.12,;3.09,.81,;.33,.04,;-.71,-1.1,;-2.11,-.47,;-3.45,-1.24,;-4.78,-.47,;-4.78,1.07,;-6.11,1.84,;-7.45,1.07,;-8.78,1.84,;-10.11,1.07,;-10.11,-.47,;-8.78,-1.24,;-7.45,-.47,;-6.11,-1.24,;-6.11,-2.78,;-1.95,1.06,;-.44,1.38,;.18,2.78,;5.54,-.63,;6.12,-2.06,;7.64,-2.27,;8.59,-1.06,;10.11,-1.27,;8.01,.37,;6.49,.58,)|
Structure:
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