Reaction Details Report a problem with these data
Target
Retinol-binding protein 4
Ligand
BDBM249529
Substrate
n/a
Meas. Tech.
Scintillation Proximity Binding Assay
IC50
15.9±n/a nM
Citation
 Petrukhin, K; Cioffi, C; Johnson, G; Allikmets, R; Freeman, E; Chen, P; Conlon, M; Zhu, L Substituted 4-phenylpiperidines, their preparation and use US Patent  US10913746 Publication Date 2/9/2021 
Target
Name:
Retinol-binding protein 4
Synonyms:
PRBP | Plasma retinol-binding protein | RBP | RBP4 | RET4_HUMAN | Retinol-binding protein 4 | Retinol-binding protein 4 (RBP4) | spa binding assay for rbp4
Type:
Protein
Mol. Mass.:
23008.75
Organism:
Homo sapiens (Human)
Description:
P02753
Residue:
201
Sequence:
MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL
  
Inhibitor
Name:
BDBM249529
Synonyms:
US10072016, Compound 127 | US10407433, Compound 127 | US10913746, Compound 127 | US11649240, Compound 127 | US9434727, 127 | US9777010, Compound 127
Type:
Small organic molecule
Emp. Form.:
C22H25F5N4O2
Mol. Mass.:
472.4515
SMILES:
COCCN1CCc2[nH]nc(C(=O)N3CCC(CC3)c3cc(F)cc(F)c3C(F)(F)F)c2C1
Structure:
Search PDB for entries with ligand similarity: