Target
Ubiquitin carboxyl-terminal hydrolase 25
Ligand
BDBM482015
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
<200±n/a nM
Citation
 Guerin, DJBair, KWCaravella, JAIoannidis, Jr., SLancia, Jr., DRLi, HMischke, SNg, PYRichard, DSchiller, SEShelekhin, TWang, Z Thienopyridine carboxamides as ubiquitin-specific protease inhibitors US Patent  US10913753 Publication Date 2/9/2021 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 25
Synonyms:
3.4.19.12 | Deubiquitinating enzyme 25 | UBP25_HUMAN | USP on chromosome 21 | USP21 | USP25 | Ubiquitin carboxyl-terminal hydrolase 25 | Ubiquitin thioesterase 25 | Ubiquitin-specific-processing protease 25
Type:
PROTEIN
Mol. Mass.:
122185.70
Organism:
Homo sapiens
Description:
ChEMBL_118220
Residue:
1055
Sequence:
MTVEQNVLQQSAAQKHQQTFLNQLREITGINDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRETGITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFYGRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSENSGKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYALEFASSKPVCTSPVDDIDASSPPSGSIPSQTLPSTTEQQGALSSELPSTSPSSVAAISSRSVIHKPFTQSRIPPDLPMHPAPRHITEEELSVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASAYCLMYINDKAQFLIQEEFNKETGQPLVGIETLPPDLRDFVEEDNQRFEKELEEWDAQLAQKALQEKLLASQKLRESETSVTTAQAAGDPEYLEQPSRSDFSKHLKEETIQIITKASHEHEDKSPETVLQSAIKLEYARLVKLAQEDTPPETDYRLHHVVVYFIQNQAPKKIIEKTLLEQFGDRNLSFDERCHNIMKVAQAKLEMIKPEEVNLEEYEEWHQDYRKFRETTMYLIIGLENFQRESYIDSLLFLICAYQNNKELLSKGLYRGHDEELISHYRRECLLKLNEQAAELFESGEDREVNNGLIIMNEFIVPFLPLLLVDEMEEKDILAVEDMRNRWCSYLGQEMEPHLQEKLTDFLPKLLDCSMEIKSFHEPPKLPSYSTHELCERFARIMLSLSRTPADGR
  
Inhibitor
Name:
BDBM482015
Synonyms:
US10913753, Compound I-82
Type:
Small organic molecule
Emp. Form.:
C27H29N5OS
Mol. Mass.:
471.617
SMILES:
Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1-c1ccccc1)N1CCNCC1
Structure:
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