Target
Ubiquitin carboxyl-terminal hydrolase 28
Ligand
BDBM482139
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
<200±n/a nM
Citation
 Guerin, DJBair, KWCaravella, JAIoannidis, Jr., SLancia, Jr., DRLi, HMischke, SNg, PYRichard, DSchiller, SEShelekhin, TWang, Z Thienopyridine carboxamides as ubiquitin-specific protease inhibitors US Patent  US10913753 Publication Date 2/9/2021 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 28
Synonyms:
3.4.19.12 | Deubiquitinating enzyme 28 | KIAA1515 | UBP28_HUMAN | USP28 | Ubiquitin carboxyl-terminal hydrolase 28 | Ubiquitin thioesterase 28 | Ubiquitin-specific-processing protease 28
Type:
PROTEIN
Mol. Mass.:
122456.92
Organism:
Homo sapiens
Description:
ChEMBL_105199
Residue:
1077
Sequence:
MTAELQQDDAAGAADGHGSSCQMLLNQLREITGIQDPSFLHEALKASNGDITQAVSLLTDERVKEPSQDTVATEPSEVEGSAANKEVLAKVIDLTHDNKDDLQAAIALSLLESPKIQADGRDLNRMHEATSAETKRSKRKRCEVWGENPNPNDWRRVDGWPVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNVLENCRSHTEKRNIMFMQELQYLFALMMGSNRKFVDPSAALDLLKGAFRSSEEQQQDVSEFTHKLLDWLEDAFQLAVNVNSPRNKSENPMVQLFYGTFLTEGVREGKPFCNNETFGQYPLQVNGYRNLDECLEGAMVEGDVELLPSDHSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQIIYMDRYMYRSKELIRNKRECIRKLKEEIKILQQKLERYVKYGSGPARFPLPDMLKYVIEFASTKPASESCPPESDTHMTLPLSSVHCSVSDQTSKESTSTESSSQDVESTFSSPEDSLPKSKPLTSSRSSMEMPSQPAPRTVTDEEINFVKTCLQRWRSEIEQDIQDLKTCIASTTQTIEQMYCDPLLRQVPYRLHAVLVHEGQANAGHYWAYIYNQPRQSWLKYNDISVTESSWEEVERDSYGGLRNVSAYCLMYINDKLPYFNAEAAPTESDQMSEVEALSVELKHYIQEDNWRFEQEVEEWEEEQSCKIPQMESSTNSSSQDYSTSQEPSVASSHGVRCLSSEHAVIVKEQTAQAIANTARAYEKSGVEAALSEVMLSPAMQGVILAIAKARQTFDRDGSEAGLIKAFHEEYSRLYQLAKETPTSHSDPRLQHVLVYFFQNEAPKRVVERTLLEQFADKNLSYDERSISIMKVAQAKLKEIGPDDMNMEEYKKWHEDYSLFRKVSVYLLTGLELYQKGKYQEALSYLVYAYQSNAALLMKGPRRGVKESVIALYRRKCLLELNAKAASLFETNDDHSVTEGINVMNELIIPCIHLIINNDISKDDLDAIEVMRNHWCSYLGQDIAENLQLCLGEFLPRLLDPSAEIIVLKEPPTIRPNSPYDLCSRFAAVMESIQGVSTVTVK
  
Inhibitor
Name:
BDBM482139
Synonyms:
US10913753, Compound I-206
Type:
Small organic molecule
Emp. Form.:
C22H26FN5OS
Mol. Mass.:
427.538
SMILES:
CCc1nc2sc(C(=O)NCCc3ccc(cc3)N3CCNCC3)c(N)c2cc1F
Structure:
Search PDB for entries with ligand similarity: