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Target
Complement factor D
Ligand
BDBM482847
Substrate
n/a
Meas. Tech.
Human Factor D Assay
IC50
>10000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X; Greenlee, W Amide compounds for treatment of immune and inflammatory disorders US Patent  US10919884 Publication Date 2/16/2021 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM482847
Synonyms:
5-(3,3- difluoropiperidine- 1-carboxamido)-1- (2-((2S,4R)-4- fluoro-2-((S)-1- hydroxy-2-(6- methylpyridin-2- yl)ethyl)pyrrolidin- 1-yl)-2-oxoethyl)- 1H-indole-3- carboxamide | US10919884, Cmp No. 3 | US11649229, Cmp No. 3
Type:
Small organic molecule
Emp. Form.:
C29H33F3N6O4
Mol. Mass.:
586.6053
SMILES:
Cc1cccc(CC(O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2cc(C(N)=O)c3cc(NC(=O)N4CCCC(F)(F)C4)ccc23)n1 |r|
Structure:
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