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Target
Histone deacetylase 1
Ligand
BDBM483369
Substrate
n/a
Meas. Tech.
Reporter Displacement Assay
Kd
6250±n/a nM
Citation
 Jefson, MR; Lowe, III, JA; Dey, F; Bergmann, A; Schoop, A; Fuller, NO Hetero-halo inhibitors of histone deacetylase US Patent  US10919902 Publication Date 2/16/2021 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM483369
Synonyms:
US10919902, Compound 113
Type:
Small organic molecule
Emp. Form.:
C19H15F2N5O
Mol. Mass.:
367.3521
SMILES:
Nc1ccc(-c2ccc(F)cc2)c(F)c1NC(=O)N1Cc2nccnc2C1
Structure:
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