Target
Fatty acid 2-hydroxylase
Ligand
BDBM483681
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling
IC50
550±n/a nM
Citation
 Grice, CAWiener, JJWeber, ODDuncan, KK Pyrazole MAGL inhibitors US Patent  US10927105 Publication Date 2/23/2021 
Target
Name:
Fatty acid 2-hydroxylase
Synonyms:
FA2H | FA2H_HUMAN | FAAH | FAXDC1 | Fatty acid alpha-hydroxylase | Fatty acid hydroxylase domain-containing protein 1
Type:
Protein
Mol. Mass.:
42806.38
Organism:
Human
Description:
Q7L5A8
Residue:
372
Sequence:
MAPAPPPAASFSPSEVQRRLAAGACWVRRGARLYDLSSFVRHHPGGEQLLRARAGQDISADLDGPPHRHSANARRWLEQYYVGELRGEQQGSMENEPVALEETQKTDPAMEPRFKVVDWDKDLVDWRKPLLWQVGHLGEKYDEWVHQPVTRPIRLFHSDLIEGLSKTVWYSVPIIWVPLVLYLSWSYYRTFAQGNVRLFTSFTTEYTVAVPKSMFPGLFMLGTFLWSLIEYLIHRFLFHMKPPSDSYYLIMLHFVMHGQHHKAPFDGSRLVFPPVPASLVIGVFYLCMQLILPEAVGGTVFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYSLKAHHVKHHFAHQKSGFGISTKLWDYCFHTLTPEKPHLKTQ
  
Inhibitor
Name:
BDBM483681
Synonyms:
1-(5-(3-chloro-5- (trifluoromethyl)- benzyl)- octahydropyrrolo- [3,4-c]pyrrole-2- carbonyl)-1H- pyrazole-3- carboxylic acid | US10927105, Ex 124 | US11655217, Example 124
Type:
Small organic molecule
Emp. Form.:
C19H18ClF3N4O3
Mol. Mass.:
442.819
SMILES:
OC(=O)c1ccn(n1)C(=O)N1CC2CN(Cc3cc(Cl)cc(c3)C(F)(F)F)CC2C1
Structure:
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