Target
Monoglyceride lipase
Ligand
BDBM483705
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling
IC50
<100±n/a nM
Citation
 Grice, CAWiener, JJWeber, ODDuncan, KK Pyrazole MAGL inhibitors US Patent  US10927105 Publication Date 2/23/2021 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM483705
Synonyms:
1-(cis-5-([1,1'- biphenyl]-3- yloxy)- octahydrocyclopenta- [c]pyrrole-2- carbonyl)-1H- pyrazole-3- carboxylic acid | US10927105, Ex 164 | US11655217, Example 164
Type:
Small organic molecule
Emp. Form.:
C24H23N3O4
Mol. Mass.:
417.4571
SMILES:
OC(=O)c1ccn(n1)C(=O)N1C[C@@H]2C[C@@H](C[C@@H]2C1)Oc1cccc(c1)-c1ccccc1 |r|
Structure:
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