Reaction Details Report a problem with these data
Target
Fatty acid 2-hydroxylase
Ligand
BDBM483709
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling
IC50
<100±n/a nM
Citation
 Grice, CA; Wiener, JJ; Weber, OD; Duncan, KK Pyrazole MAGL inhibitors US Patent  US10927105 Publication Date 2/23/2021 
Target
Name:
Fatty acid 2-hydroxylase
Synonyms:
FA2H | FA2H_HUMAN | FAAH | FAXDC1 | Fatty acid alpha-hydroxylase | Fatty acid hydroxylase domain-containing protein 1
Type:
Protein
Mol. Mass.:
42806.38
Organism:
Human
Description:
Q7L5A8
Residue:
372
Sequence:
MAPAPPPAASFSPSEVQRRLAAGACWVRRGARLYDLSSFVRHHPGGEQLLRARAGQDISADLDGPPHRHSANARRWLEQYYVGELRGEQQGSMENEPVALEETQKTDPAMEPRFKVVDWDKDLVDWRKPLLWQVGHLGEKYDEWVHQPVTRPIRLFHSDLIEGLSKTVWYSVPIIWVPLVLYLSWSYYRTFAQGNVRLFTSFTTEYTVAVPKSMFPGLFMLGTFLWSLIEYLIHRFLFHMKPPSDSYYLIMLHFVMHGQHHKAPFDGSRLVFPPVPASLVIGVFYLCMQLILPEAVGGTVFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYSLKAHHVKHHFAHQKSGFGISTKLWDYCFHTLTPEKPHLKTQ
  
Inhibitor
Name:
BDBM483709
Synonyms:
1-(trans-5-((3- methyl-4- (trifluoromethyl)- benyl)oxy)- octahydrocyclopenta- [c]pyrrole- 2-carbonyl)-1H- pyrazole-3- carboxylic acid | US10927105, Ex 172 | US11655217, Example 172
Type:
Small organic molecule
Emp. Form.:
C21H22F3N3O4
Mol. Mass.:
437.4123
SMILES:
Cc1cc(CO[C@@H]2C[C@H]3CN(C[C@H]3C2)C(=O)n2ccc(n2)C(O)=O)ccc1C(F)(F)F |r|
Structure:
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