Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM483723
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling
IC50
<100±n/a nM
Citation
 Grice, CA; Wiener, JJ; Weber, OD; Duncan, KK Pyrazole MAGL inhibitors US Patent  US10927105 Publication Date 2/23/2021 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM483723
Synonyms:
1-(5-(3- (trifluoromethyl)- benzyl)- octahydropyrrolo- [3,4-c]pyrrole-2- carbonyl)-1H- pyrazole-3- carboxamide | US10927105, Ex 208 | US11655217, Example 208
Type:
Small organic molecule
Emp. Form.:
C19H20F3N5O2
Mol. Mass.:
407.3896
SMILES:
NC(=O)c1ccn(n1)C(=O)N1CC2CN(Cc3cccc(c3)C(F)(F)F)CC2C1
Structure:
Search PDB for entries with ligand similarity: