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Target
Ubiquitin carboxyl-terminal hydrolase 30
Ligand
BDBM483946
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
5500±n/a nM
Citation
 Stockley, ML; Kemp, MI Cyano-subtituted heterocycles with activity as inhibitors of USP30 US Patent  US10927110 Publication Date 2/23/2021 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 30
Synonyms:
Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30
Type:
Protein
Mol. Mass.:
58522.90
Organism:
Homo sapiens (Human)
Description:
Q70CQ3
Residue:
517
Sequence:
MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
  
Inhibitor
Name:
BDBM483946
Synonyms:
(R)-2′-(5-(1-cyano-3-fluoropiperidin-3-yl)-1,3,4-oxadiazol-2-yl)-[4,4′-bipyridine]-2-carbonitrile | US10927110, Example 13
Type:
Small organic molecule
Emp. Form.:
C19H14FN7O
Mol. Mass.:
375.3592
SMILES:
F[C@@]1(CCCN(C1)C#N)c1nnc(o1)-c1cc(ccn1)-c1ccnc(c1)C#N |r|
Structure:
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