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Target
RAF proto-oncogene serine/threonine-protein kinase
Ligand
BDBM484015
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
<0.1±n/a nM
Citation
 Kaldor, SW; Kanouni, T; Arnold, L Inhibitors of RAF kinases US Patent  US10927111 Publication Date 2/23/2021 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase
Synonyms:
C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase RAF | Serine/threonine-protein kinase C-Raf | cRaf
Type:
Serine/threonine-protein kinase
Mol. Mass.:
73082.52
Organism:
Homo sapiens (Human)
Description:
P04049
Residue:
648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM484015
Synonyms:
(3R)-N-[2-fluoro-4-methyl-5-[7- methyl-2-(methylamino)pyrido[2,3- d]pyrimidin-6-yl]phenyl]-3-(2,2,2- trifluoroethoxy)pyrrolidine-1- carboxamide | US10927111, Example 51 | US11667634, Example 51
Type:
Small organic molecule
Emp. Form.:
C23H24F4N6O2
Mol. Mass.:
492.4693
SMILES:
CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC[C@H](C2)OCC(F)(F)F)c(F)cc1C |r|
Structure:
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