Target
RAF proto-oncogene serine/threonine-protein kinase
Ligand
BDBM484031
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
<0.1±n/a nM
Citation
 Kaldor, SWKanouni, TArnold, L Inhibitors of RAF kinases US Patent  US10927111 Publication Date 2/23/2021 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase
Synonyms:
C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase RAF | Serine/threonine-protein kinase C-Raf | cRaf
Type:
Serine/threonine-protein kinase
Mol. Mass.:
73082.52
Organism:
Homo sapiens (Human)
Description:
P04049
Residue:
648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM484031
Synonyms:
N-[3-[7-ethynyl-2- (methylamino)pyrido[2,3-d]pyrimidin- 6-yl]-4-methylphenyl]-2- (trifluoromethyl)pyridine-4- carboxamide | US10927111, Example 67 | US10927111, Example 72 | US11667634, Example 72
Type:
Small organic molecule
Emp. Form.:
C23H16F3N7O
Mol. Mass.:
463.4146
SMILES:
CNc1ncc2cc(c(nc2n1)C#N)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Structure:
Search PDB for entries with ligand similarity: