Target
SH2B adapter protein 2
Ligand
BDBM484434
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
789±n/a nM
Citation
 Chen, ZFortanet, JGKarki, RLamarche, MJMajumdar, DPerez, LBSendzik, MSmith, TDYang, FYu, B Compounds and compositions for inhibiting the activity of SHP2 US Patent  US10934285 Publication Date 3/2/2021 
Target
Name:
SH2B adapter protein 2
Synonyms:
APS | Adapter protein with pleckstrin homology and Src homology 2 domains | SH2 and PH domain-containing adapter protein APS | SH2B2 | SH2B2_HUMAN
Type:
Protein
Mol. Mass.:
67733.52
Organism:
Human
Description:
O14492
Residue:
632
Sequence:
MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGASFSRHFAANFLDVFGEEVRRVLVAGPTTRGAAVSAEAMEPELADTSALKAAPYGHSRSSEDVSTHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEPRDKWTRRLRLSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAEERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVVTAPHSRGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPTPPAAPASPACWSDSPGQHYFSSLAAAACPPASPSDAAGASSSSASSSSAASGPAPPRPVEGQLSARSRSNSAERLLEAVAATAAEEPPEAAPGRARAVENQYSFY
  
Inhibitor
Name:
BDBM484434
Synonyms:
US10934285, Example 18
Type:
Small organic molecule
Emp. Form.:
C25H22ClF3N8O3S
Mol. Mass.:
607.007
SMILES:
NC(C1CCN(C1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4ccccn4c3=O)c2Cl)c(N)n1)C(F)(F)F
Structure:
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