Reaction Details Report a problem with these data
Target
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)
Ligand
BDBM484517
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
Ki
>608±n/a nM
Citation
 Arasappan, A; Cox, JM; Debenham, JS; Guo, Z; He, J; Hussain, Z; Lai, Z; Li, D; Meng, D; Raghavan, S; Tyagarajan, S Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors US Patent  US10934294 Publication Date 3/2/2021 
Target
Name:
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)
Synonyms:
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2) | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A (PDE9A2) | Phosphodiesterase 9A2
Type:
Protein
Mol. Mass.:
61702.98
Organism:
Homo sapiens (Human)
Description:
O76083-2
Residue:
533
Sequence:
MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
  
Inhibitor
Name:
BDBM484517
Synonyms:
US10934294, Example 38 | US10934294, Example 39 | US10934294, Example 40 | US10934294, Example 41 | US10934294, Example 42 | US10934294, Example 43 | US10934294, Example 44 | US10934294, Example 45 | US11028092, Example 45
Type:
Small organic molecule
Emp. Form.:
C22H18F2N8O
Mol. Mass.:
448.4281
SMILES:
CC(c1ccc(nc1)C(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
Structure:
Search PDB for entries with ligand similarity: