Target
SH2B adapter protein 2
Ligand
BDBM484752
Substrate
n/a
Meas. Tech.
Allosteric Inhibition Assay
IC50
<50±n/a nM
Citation
 Taylor, AMLescarbeau, AKelley, EHShortsleeves, KCWalters, WPMurcko, MAGiordanetto, FTherrien, E SHP2 phosphatase inhibitors and methods of use thereof US Patent  US10934302 Publication Date 3/2/2021 
Target
Name:
SH2B adapter protein 2
Synonyms:
APS | Adapter protein with pleckstrin homology and Src homology 2 domains | SH2 and PH domain-containing adapter protein APS | SH2B2 | SH2B2_HUMAN
Type:
Protein
Mol. Mass.:
67733.52
Organism:
Human
Description:
O14492
Residue:
632
Sequence:
MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGASFSRHFAANFLDVFGEEVRRVLVAGPTTRGAAVSAEAMEPELADTSALKAAPYGHSRSSEDVSTHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEPRDKWTRRLRLSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAEERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVVTAPHSRGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPTPPAAPASPACWSDSPGQHYFSSLAAAACPPASPSDAAGASSSSASSSSAASGPAPPRPVEGQLSARSRSNSAERLLEAVAATAAEEPPEAAPGRARAVENQYSFY
  
Inhibitor
Name:
BDBM484752
Synonyms:
1-(4-{6-[(3R)-3-amino-1,3-dihydrospiro[indene-2,4′-piperidin]-1′-yl]-1H-pyrazolo[3,4-b]pyrazin-3-yl}-1,2,3,4-tetrahydroquinoxalin-1-yl)ethan-1-one (RTX-1084025) and (1-(4-{6-[(3S)-3-amino-1,3-dihydrospiro[indene-2,4′-piperidin]-1′-yl]-1H-pyrazolo[3,4-b]pyrazin-3-yl}-1,2,3,4-tetrahydroquinoxalin-1-yl)ethan-1-one | US10934302, Example 1
Type:
Small organic molecule
Emp. Form.:
C28H30N8O
Mol. Mass.:
494.5908
SMILES:
CC(=O)N1CCN(c2n[nH]c3nc(cnc23)N2CCC3(Cc4ccccc4[C@@H]3N)CC2)c2ccccc12 |r|
Structure:
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