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Target
Neuroepithelial cell-transforming gene 1 protein
Ligand
BDBM485767
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
300±n/a nM
Citation
 Almansa-Rosales, C; Yenes-Mínguez, S; Virgili-Bernado, M; Alonso-Xalma, M Quinoline and isoquinoline derivatives for treating pain and pain related conditions US Patent  US10941138 Publication Date 3/9/2021 
Target
Name:
Neuroepithelial cell-transforming gene 1 protein
Synonyms:
ARHG8_HUMAN | ARHGEF8 | NET1 | Proto-oncogene p65 Net1 | Rho guanine nucleotide exchange factor 8
Type:
PROTEIN
Mol. Mass.:
67762.41
Organism:
Homo sapiens
Description:
ChEMBL_118125
Residue:
596
Sequence:
MEPELAAQKQPRPRRRSRRASGLSTEGATGPSADTSGSELDGRCSLRRGSSFTFLTPGPNWDFTLKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKETLV
  
Inhibitor
Name:
BDBM485767
Synonyms:
(S)-N-methyl-3-((1- methylisoquinolin-5- yl)oxy)-3-(thiophen-2- yl)propan-1-amine | US10941138, Example 65
Type:
Small organic molecule
Emp. Form.:
C18H20N2OS
Mol. Mass.:
312.429
SMILES:
CNCC[C@H](Oc1cccc2c(C)nccc12)c1cccs1 |r|
Structure:
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