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Target
Neuroepithelial cell-transforming gene 1 protein
Ligand
BDBM485784
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
300±n/a nM
Citation
 Almansa-Rosales, C; Yenes-Mínguez, S; Virgili-Bernado, M; Alonso-Xalma, M Quinoline and isoquinoline derivatives for treating pain and pain related conditions US Patent  US10941138 Publication Date 3/9/2021 
Target
Name:
Neuroepithelial cell-transforming gene 1 protein
Synonyms:
ARHG8_HUMAN | ARHGEF8 | NET1 | Proto-oncogene p65 Net1 | Rho guanine nucleotide exchange factor 8
Type:
PROTEIN
Mol. Mass.:
67762.41
Organism:
Homo sapiens
Description:
ChEMBL_118125
Residue:
596
Sequence:
MEPELAAQKQPRPRRRSRRASGLSTEGATGPSADTSGSELDGRCSLRRGSSFTFLTPGPNWDFTLKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKETLV
  
Inhibitor
Name:
BDBM485784
Synonyms:
(S)-3-(3-Fluorothiophen-2-yl)-3-(isoquinolin-5-yloxy)-N-methylpropan-1-amine and (R)-3-(3-fluorothiophen-2-yl)-3-(isoquinolin-5-yloxy)-N-methylpropan-1-amine | US10941138, Example 82 | US10941138, Example 83
Type:
Small organic molecule
Emp. Form.:
C17H17FN2OS
Mol. Mass.:
316.393
SMILES:
CNCC[C@H](Oc1cccc2cnccc12)c1sccc1F |r|
Structure:
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