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Target
Beta-1 adrenergic receptor
Ligand
BDBM485867
Substrate
n/a
Meas. Tech.
cAMP Gs dynamic HTRF assay
EC50
55±n/a nM
Citation
 Ford, AP; Chen, W; Carter, DS; Yu, J Beta adrenergic agonist and methods of using the same US Patent  US10947196 Publication Date 3/16/2021 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM485867
Synonyms:
US10947196, Compound 03-3
Type:
Small organic molecule
Emp. Form.:
C12H17F3N2O
Mol. Mass.:
262.2714
SMILES:
CC(C)(C)NC[C@H](O)c1cccc(n1)C(F)(F)F |r|
Structure:
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